Research surrounding other prohormones and prohormone supplements is limited, so many side effects are unknown regarding both legal and illegal prohormone supplements. Prohormone supplements became popular from 1960 to 2001 and became used unregulated in Major League Baseball before select prohormones such as androstenedione and androstenediol became banned in the United States' Anabolic Steroid Control Act of 2004. Examples of natural, human prohormones include proinsulin and pro-opiomelanocortin, but the most widespread prohormones in use are synthetic and labeled as anabolic steroid precursors, used as ergogenic or anabolic agents for muscle growth. Many prohormones affect the body stronger than others and may cause more side effects. Prohormones act like precursors to natural hormones in the human body, activating them. It is important to note that the use of prohormones is banned in many sports organizations and can also be illegal in some countries. Prohormones contain strong properties which bring both positive effects alongside potential risks. In the past, similar products were sought after for their potential to bridge the gap between natural bodybuilding and the use of controlled substances. The appeal of such formulations lies in the promise of accelerated gains compared to natural training and supplementation. At AO Nutrition we strive to provide our community with sound knowledge and quality supplements that take your fitness and strength to the next level. Protocols typically involve selective estrogen receptor modulators (SERMs) and potentially other supportive compounds. The body turns prohormones into anabolic hormones which duplicate the steroid-like effects of anabolic steroids. The human body converts prohormones into anabolic hormones naturally during its biological processes. The fitness and bodybuilding world has long discussed prohormones because these compounds are known to boost muscle growth and athletic performance. Chronic effects of A-dione in men may slightly and inconsistently increase muscle mass and strength in men with low test levels, it's not much more effective than performance resistance training alone and less effective than using testosterone replacement therapy (TRT).The acute effects of A-diol in men appears to significantly increase estrogen levels without positively affecting test levels. Based on the outcome of this study, the downsides may outweigh the upsides of supplementing with prohormones.Another study examines four different compounds - androstenedione, androstenediol, norandrostenedione, and norandrostenediol. Based on these findings prohormones look like an extremely effective way to drop fat and increase both muscle and strength. If you have any questions, comments, or firsthand experiences with prohormones, let me know is the comments section below. Now that you've been armed with a slew of information on prohormones, I encourage you to perform your due-diligence and determine if prohormones are right for you. This means while you may experience moderate-high increases in strength and muscle mass and/or decreases in fat mass, you are equally as likely to experience a moderate or high number of external and/or internal side effects.